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Antes de nada...

First of all... / Before anything else... / To begin with...

Sentence Frames
Notes & Usage:

Used to introduce the very first point or action, establishing priority. Slightly more emphatic than en primer lugar.

See It in Context

Antes de nada, quiero agradeceros vuestra presencia.

First of all, I want to thank you all for being here.

Antes de nada, necesito saber cuál es el problema exacto.

Before anything else, I need to know what the exact problem is.

Antes de nada, ¿todos tienen el documento?

First of all, does everyone have the document?